Create a melatonin/vitamin ODF with pleasant taste and instant perceived effect, maintaining consistent release across flavor variants.
Approach
Matrix: Pullulan/HPMC; polyols + HIS sweeteners for sugar-free profile.
Actives: Melatonin 3 mg/strip; light vitamin fortification.
Sensory: Berry + mint top notes; staged cooling at 0.04%.
Process/pack similar to Pharma; cap flavor load at 1.2% to manage hygroscopicity.
Data
Methods: Same as Pharma; active measured as melatonin where applicable.
Disintegration: Median 15 s (n = 24), RSD 9%.
Dissolution (melatonin): 2 min 58% ± 7%; 5 min 86% ± 6%.
Mechanics: Thickness 65 µm; tensile 16 MPa; elongation 80%; low-RH (30%RH) brittleness rate 0.5%.
Stability (6 mo accelerated): Assay 97–103%; color ΔE < 2; 5-min dissolution variation ≤ ±8%; unit sachets show no blocking within 30 min after opening.
Outcome & Value
Strong sensory acceptance with instant freshness; consistent release across flavors and low hygroscopic design improve shelf life and repurchase rates.